TOXICOLOGICAL SAFETY PROFILE ANTI-TUBERCULOSIS DRUG «RIFABUTIN» WITH A SINGLE INJECTION IN EXPERIMENTAL CONDITIONS
نویسندگان
چکیده
The article is devoted to an experimental study determine the toxicological safety profile of anti-tuberculosis drug "Rifabutin" when administered once linear and nonlinear animals (mice, rats, rabbits)
منابع مشابه
Safety of rifabutin replacing rifampicin in the treatment of tuberculosis: a single-centre retrospective cohort study.
OBJECTIVES The safety of rifabutin replacing rifampicin among adults having rifampicin-related adverse reactions (ARs) during the treatment of tuberculosis remains unknown. METHODS From June 2006 to June 2010, a total of 2868 newly treated tuberculosis patients without HIV infection in a referral hospital were screened in this retrospective cohort study. RESULTS Among the screened patients,...
متن کاملA Rare Etiology of Drug Rash in a Patient Receiving Anti-Tuberculosis Treatment
Anti-tuberculosis medications can cause various side effects, including drug rash. When a patient on anti-tuberculosis treatment (ATT) develops rash, we usually stop all medicines, rechallenge the patient with medications individually, and find the offending agent. It should be mentioned that drug rash can be also a manifestation of other diseases. Herein, we report a case of tuberculosis who d...
متن کاملA STUDY OF MYCOBACTERIUM TUBERCULOSIS DRUG RESISTANCE IN PULMONARY TUBERCULOSIS
Tuberculosis remains a major public health problem in both developing and developed countries. Drug-resistant tuberculosis is an increasing health problem and serious challenge to tuberculosis (TB) control programs. Information about the susceptibility pattern of Mycobacterium tuberculosis isolates against anti-tuberculosis drugs is an important aspect to TB control. The objectives of the s...
متن کاملAnti-Tuberculosis Drug-Induced Hepatotoxicity: A Review
Hepatotoxicity, a serious adverse drug reaction in tuberculosis (TB) patients receiving anti-TB drugs, is one of the most challenging clinical problems worldwide. Despite increasing awareness of clinicians and public, even now it remains an enormous problem and causes of hospitalization and life-threatening events. Considering the importance of anti-TB drug-induced hepatotoxicity (DIH) as a maj...
متن کاملMolecular detection of rifabutin-susceptible Mycobacterium tuberculosis.
Rapid assays are still needed to detect rifabutin (RFB) susceptibility for proper tuberculosis treatment. To assess the use of the GenoType MTBDRplus assay and subsequent rpoB gene sequencing on detection of RFB susceptibility, we analyzed 800 multidrug-resistant Mycobacterium tuberculosis isolates, and 13% (104/800) were RFB susceptible. Of the 104 RFB-susceptible isolates, 71 (68.3%) isolates...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Vestnik Angarskogo gosudarstvennogo tehni?eskogo universiteta
سال: 2022
ISSN: ['2686-777X']
DOI: https://doi.org/10.36629/2686-777x-2022-1-16-215-218